When a user is trying to run a script on a shared drive or remote desktop they are seeing the error "Please open data file before continuing". Even thought the file is already open. If the user saves the file to their local desktop they can run without issues through Studio.
Staring in 12.1 this is as designed behavior when working with OneDrive.
1. Right-click on the One-drive icon and go to settings.(Screenshot attached)
2. Go to Office tab .
3. Uncheck the option "Use Office applications to sync Office files..."
4. Click Ok.
5. Then try running the scenario and let us know the results.
Improvement https://jira.wswork.biz/browse/WIN-37902 has been logged in JIRA.